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High doses of corticosteroid suppress resistance to Ichthyophonus in starry flounder

Journal of Aquatic Animal Health

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Abstract

Application of pharmacological doses of the corticosteroid dexamethasone phosphate to starry flounder Platichthys stellatus resulted in a predisposition to clinical ichthyophoniasis and a progression from latent Ichthyophonus infections to patent, histologically identifiable infections. Among Ichthyophonus-challenged starry flounder, the prevalences of clinical infections and histologically identifiable infections were significantly greater in two groups that received dexamethasone (100% and 31%, respectively) than in the respective control groups (8% and 0%). Proliferation of Ichthyophonus infections in corticosteroid-treated groups may have resulted from suppression of the cellular immune response that typically follows corticosteroid application; however, further studies are needed to determine whether these effects occur at lower, physiological concentrations of corticosteroids.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
High doses of corticosteroid suppress resistance to Ichthyophonus in starry flounder
Series title:
Journal of Aquatic Animal Health
Volume
16
Issue:
1
Year Published:
2004
Language:
English
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Journal of Aquatic Animal Health
First page:
45
Last page:
49
Number of Pages:
5