Effects of depleted uranium on survival, growth, and metamorphosis in the african clawed frog (Xenopus laevis)

Mitchell, S. E.; Caldwell, C. A.; Gonzales, G.; Gould, W. R.; Arimoto, R.

Abstract:

Embryos (stage 8-47, Nieuwkoop and Faber) of the African clawed frog (Xenopus laevis) were subjected to water-borne depleted uranium (DU) concentrations that ranged from 4.8 to 77.7 mg/Lusing an acute 96-h frog embryo teratogenesis assay-Xenopus (FETAX). In a chronic 64-d assay, X. laevis (from embryo through metamorphosis; stages 8-66) were subjected to concentrations of DU that ranged from 6.2 to 54.3 mg/L Our results indicate DU is a non teratogenic metal. No effects on mortality, malformations, or growth were observed in the 96-h FETAX with concentrations of DU that ranged from 4.8 to 77.7 mg/L From stage 8 to stage 47, X. laevis tadpoles do not actively feed and the gills are not well developed. Thus, uptake of DU was reduced despite exposure to elevated concentrations. The 64-d assay resulted in no concentration response for either mortality or malformations; however, a delay in metamorphosis was observed in tadpoles subjected to elevated DU concentrations (from 13.1 to 54.3 mg/L) compared to tadpoles in both the well-water control and reference. The delay in metamorphosis was likely due to increasing body burden of DU that ranged from 0.98 to 2.82 mg/kg. Copyright?? Taylor & Francis Inc.

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Conference Paper

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70029684

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Mitchell, S. E.; Caldwell, C. A.; Gonzales, G.; Gould, W. R.; Arimoto, R.

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956

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11-12

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English

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Journal of Toxicology and Environmental Health - Part A

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Effects of depleted uranium on survival, growth, and metamorphosis in the african clawed frog (Xenopus laevis); 2005; Conference Paper; Journal of Toxicology and Environmental Health - Part A; Mitchell, S. E.; Caldwell, C. A.; Gonzales, G.; Gould, W. R.; Arimoto, R.