| Abstract: | White-tailed deer (n = 14 treated, n = 7 control) were examined postmortem to identify any possible pathophysiology resulting from PZP immunocontraception vaccination. Deer were treated twice in 1997; given a booster in 1998, with six being revaccinated in September 2000. Granulomas were found at injection sites of most deer, even 2 years post-treatment. Eosinophilic oophoritis occurred in 6 of 8 (75%) deer vaccinated in 1998, and 3 of 6 (50%) revaccinated in 2000. The 2000 revaccinates without oophoritis, had significantly fewer normal secondary follicles than control females (P = 0.03), and deer in the1998 treatment group (P = 0.04). PZP immunocontraceptive vaccine elicited ovarian pathologies in deer similar to those observed in other species. ?? 2007 Elsevier Ltd. All rights reserved. |
| Genre: | Article |
| ProdID: | 70030170 |
| Citation Author: | Curtis, P. D.; Richmond, M. E.; Miller, L. A.; Quimby, F. W. |
| Citation Contributing Office: | |
| Citation Datum: | |
| Citation Day: | |
| Citation Edition: | |
| Citation Editor: | |
| Citation End Page: | 4630 |
| Citation Issue: | 23 |
| Citation Keywords: | |
| Citation Language: | English |
| Citation Larger Work Title: | Vaccine |
| Citation LatN: | |
| Citation LatS: | |
| Citation LonE: | |
| Citation LonW: | |
| Citation Month: | |
| Citation No Pagination: | |
| Citation Number Of Pages: | 8 |
| Citation Online Only Flag: | |
| Citation Phsyical Description: | |
| Citation Projection: | |
| Citation Public Comments: | |
| Citation Publisher: | |
| Citation Series: | |
| Citation Series Code: | |
| Citation Series Number: | |
| Citation Search Results Text: | Pathophysiology of white-tailed deer vaccinated with porcine zona pellucida immunocontraceptive; 2007; Article; Journal; Vaccine; Curtis, P. D.; Richmond, M. E.; Miller, L. A.; Quimby, F. W. |
| Citation Start Page: | 4623 |
| Citation Volume: | 25 |
| Citation Year: | 2007 |
| Type: | citation/reference |
| Text: | Pathophysiology of white-tailed deer vaccinated with porcine zona pellucida immunocontraceptive; 2007; Article; Journal; Vaccine; Curtis, P. D.; Richmond, M. E.; Miller, L. A.; Quimby, F. W. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| URL (DIGITAL OBJECT IDENTIFIER): | http://dx.doi.org/10.1016/j.vaccine.2007.03.033 |
| Date Other: | Mon, 1 Jan 2007 00:00 -0600 |
| Publisher: | |
