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Pathophysiology of white-tailed deer vaccinated with porcine zona pellucida immunocontraceptive

Vaccine

By:
, , , and
DOI: 10.1016/j.vaccine.2007.03.033

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Abstract

White-tailed deer (n = 14 treated, n = 7 control) were examined postmortem to identify any possible pathophysiology resulting from PZP immunocontraception vaccination. Deer were treated twice in 1997; given a booster in 1998, with six being revaccinated in September 2000. Granulomas were found at injection sites of most deer, even 2 years post-treatment. Eosinophilic oophoritis occurred in 6 of 8 (75%) deer vaccinated in 1998, and 3 of 6 (50%) revaccinated in 2000. The 2000 revaccinates without oophoritis, had significantly fewer normal secondary follicles than control females (P = 0.03), and deer in the1998 treatment group (P = 0.04). PZP immunocontraceptive vaccine elicited ovarian pathologies in deer similar to those observed in other species. ?? 2007 Elsevier Ltd. All rights reserved.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Pathophysiology of white-tailed deer vaccinated with porcine zona pellucida immunocontraceptive
Series title:
Vaccine
DOI:
10.1016/j.vaccine.2007.03.033
Volume
25
Issue:
23
Year Published:
2007
Language:
English
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Vaccine
First page:
4623
Last page:
4630