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Both msa genes in Renibacterium salmoninarum are needed for full virulence in bacterial kidney disease

Applied and Environmental Microbiology

By:
, , ,
DOI: 10.1128/AEM.72.4.2672-2678.2006

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Abstract

Renibacterium salmoninarum, a gram-positive diplococcobacillus that causes bacterial kidney disease among salmon and trout, has two chromosomal loci encoding the major soluble antigen (msa) gene. Because the MSA protein is widely suspected to be an important virulence factor, we used insertion-duplication mutagenesis to generate disruptions of either the msa1 or msa2 gene. Surprisingly, expression of MSA protein in broth cultures appeared unaffected. However, the virulence of either mutant in juvenile Chinook salmon (Oncorhynchus tshawytscha) by intraperitoneal challenge was severely attenuated, suggesting that disruption of the msa1 or msa2 gene affected in vivo expression. Copyright ?? 2006, American Society for Microbiology. All Rights Reserved.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Both msa genes in Renibacterium salmoninarum are needed for full virulence in bacterial kidney disease
Series title:
Applied and Environmental Microbiology
DOI:
10.1128/AEM.72.4.2672-2678.2006
Volume
72
Issue:
4
Year Published:
2006
Language:
English
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
First page:
2672
Last page:
2678
Number of Pages:
7