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Expressed MHC class II genes in sea otters (Enhydra lutris) from geographically disparate populations

Tissue Antigens

By:
, , , and
DOI: 10.1111/j.1399-0039.2006.00559.x

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Abstract

The major histocompatibility complex (MHC) is central to maintaining the immunologic vigor of individuals and populations. Classical MHC class II genes were targeted for partial sequencing in sea otters (Enhydra lutris) from populations in California, Washington, and Alaska. Sequences derived from sea otter peripheral blood leukocyte mRNAs were similar to those classified as DQA, DQB, DRA, and DRB in other species. Comparisons of the derived amino acid compositions supported the classification of these as functional molecules from at least one DQA, DQB, and DRA locus and at least two DRB loci. While limited in scope, phylogenetic analysis of the DRB peptide-binding region suggested the possible existence of distinct clades demarcated by geographic region. These preliminary findings support the need for additional MHC gene sequencing and expansion to a comprehensive study targeting additional otters. ?? 2006 Blackwell Munksgaard.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Expressed MHC class II genes in sea otters (Enhydra lutris) from geographically disparate populations
Series title:
Tissue Antigens
DOI:
10.1111/j.1399-0039.2006.00559.x
Volume
67
Issue:
5
Year Published:
2006
Language:
English
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Tissue Antigens
First page:
402
Last page:
408
Number of Pages:
7