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Effects of enhanced zinc and copper in drinking water on spatial memory and fear conditioning

Journal of Geochemical Exploration

By:
, , , ,
DOI: 10.1016/j.gexplo.2005.08.019

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Abstract

Ingestion of enhanced zinc can cause memory impairments and copper deficiencies. This study examined the effect of zinc supplementation, with and without copper, on two types of memory. Rats raised pre- and post-natally on 10 mg/kg ZnCO3 or ZnSO4 in the drinking water were tested in a fear-conditioning experiment at 11 months of age. Both zinc groups showed a maladaptive retention of fearful memories compared to controls raised on tap water. Rats raised on 10 mg/kg ZnCO3, 10 mg/kg ZnCO3 + 0.25 mg/kg CuCl2, or tap water, were tested for spatial memory ability at 3 months of age. Significant improvements in performance were found in the ZnCO3 + CuCl2 group compared to the ZnCO3 group, suggesting that some of the cognitive deficits associated with zinc supplementation may be remediated by addition of copper. ?? 2005 Elsevier B.V. All rights reserved.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Effects of enhanced zinc and copper in drinking water on spatial memory and fear conditioning
Series title:
Journal of Geochemical Exploration
DOI:
10.1016/j.gexplo.2005.08.019
Volume
88
Issue:
1-3 SPEC. ISS.
Year Published:
2006
Language:
English
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Journal of Geochemical Exploration
First page:
91
Last page:
94
Number of Pages:
4