| Abstract: | Treated wastewater effluent is a potential environmental point source for antidepressant pharmaceuticals. A quantitative method was developed for the determination of trace levels of antidepressants in environmental aquatic matrixes using solid-phase extraction coupled with liquid chromatography- electrospray ionization tandem mass spectrometry. Recoveries of parent antidepressants from matrix spiking experiments for the individual antidepressants ranged from 72 to 118% at low concentrations (0.5 ng/L) and 70 to 118% at high concentrations (100 ng/L) for the solid-phase extraction method. Method detection limits for the individual antidepressant compounds ranged from 0.19 to 0.45 ng/L. The method was applied to wastewater effluent and samples collected from a wastewater-dominated stream. Venlafaxine was the predominant antidepressant observed in wastewater and river water samples. Individual antidepressant concentrations found in the wastewater effluent ranged from 3 (duloxetine) to 2190 ng/L (venlafaxine), whereas individual concentrations in the waste-dominated stream ranged from 0.72 (norfluoxetine) to 1310 ng/L (venlafaxine). ?? 2008 American Chemical Society. |
| Genre: | Article |
| ProdID: | 70031760 |
| Citation Author: | Schultz, M. M.; Furlong, E. T. |
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| Citation End Page: | 1762 |
| Citation Issue: | 5 |
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| Citation Language: | English |
| Citation Larger Work Title: | Analytical Chemistry |
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| Citation Number Of Pages: | 7 |
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| Citation Search Results Text: | Trace analysis of antidepressant pharmaceuticals and their select degradates in aquatic matrixes by LC/ESI/MS/MS; 2008; Article; Journal; Analytical Chemistry; Schultz, M. M.; Furlong, E. T. |
| Citation Start Page: | 1756 |
| Citation Volume: | 80 |
| Citation Year: | 2008 |
| Type: | citation/reference |
| Text: | Trace analysis of antidepressant pharmaceuticals and their select degradates in aquatic matrixes by LC/ESI/MS/MS; 2008; Article; Journal; Analytical Chemistry; Schultz, M. M.; Furlong, E. T. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| URL (DIGITAL OBJECT IDENTIFIER): | http://dx.doi.org/10.1021/ac702154e |
| Date Other: | Tue, 1 Jan 2008 00:00 -0600 |
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