| Abstract: | Atlantic salmon paramyxovirus (ASPV) was isolated in 1995 from gills of farmed Atlantic salmon suffering from proliferative gill inflammation. The complete genome sequence of ASPV was determined, revealing a genome 16,968 nucleotides in length consisting of six non-overlapping genes coding for the nucleo- (N), phospho- (P), matrix- (M), fusion- (F), haemagglutinin-neuraminidase- (HN) and large polymerase (L) proteins in the order 3???-N-P-M-F-HN-L-5???. The various conserved features related to virus replication found in most paramyxoviruses were also found in ASPV. These include: conserved and complementary leader and trailer sequences, tri-nucleotide intergenic regions and highly conserved transcription start and stop signal sequences. The P gene expression strategy of ASPV was like that of the respiro-, morbilli- and henipaviruses, which express the P and C proteins from the primary transcript and edit a portion of the mRNA to encode V and W proteins. Sequence similarities among various features related to virus replication, pairwise comparisons of all deduced ASPV protein sequences with homologous regions from other members of the family Paramyxoviridae, and phylogenetic analyses of these amino acid sequences suggested that ASPV was a novel member of the sub-family Paramyxovirinae, most closely related to the respiroviruses. ?? 2008 Elsevier B.V. All rights reserved. |
| Genre: | Article |
| ProdID: | 70032125 |
| Citation Author: | Falk, K.; Batts, W. N.; Kvellestad, A.; Kurath, G.; Wiik-Nielsen, J.; Winton, J. R. |
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| Citation End Page: | 227 |
| Citation Issue: | 2 |
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| Citation Language: | English |
| Citation Larger Work Title: | Virus Research |
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| Citation Number Of Pages: | 10 |
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| Citation Search Results Text: | Molecular characterisation of Atlantic salmon paramyxovirus (ASPV): A novel paramyxovirus associated with proliferative gill inflammation; 2008; Article; Journal; Virus Research; Falk, K.; Batts, W. N.; Kvellestad, A.; Kurath, G.; Wiik-Nielsen, J.; Winton, J. R. |
| Citation Start Page: | 218 |
| Citation Volume: | 133 |
| Citation Year: | 2008 |
| Type: | citation/reference |
| Text: | Molecular characterisation of Atlantic salmon paramyxovirus (ASPV): A novel paramyxovirus associated with proliferative gill inflammation; 2008; Article; Journal; Virus Research; Falk, K.; Batts, W. N.; Kvellestad, A.; Kurath, G.; Wiik-Nielsen, J.; Winton, J. R. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| URL (DIGITAL OBJECT IDENTIFIER): | http://dx.doi.org/10.1016/j.virusres.2008.01.006 |
| Date Other: | Tue, 1 Jan 2008 00:00 -0600 |
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