The eastern Transverse Ranges provide essentially continuous exposure for >100 km across the strike of the Mesozoic Cordilleran orogen. Thermobarometric calculations based on hornblende and plagioclase compositions in Mesozoic plutonic rocks show that the fi rst-order distribution of rock units resulted from differential Laramide exhumation. Mesozoic supracrustal rocks are preserved in the relatively little exhumed eastern part of the eastern Transverse Ranges and south-central Mojave Desert, and progressively greater rock uplift and exhumation toward the west exposed rocks originating at mid-crustal depths. The eastern Transverse Ranges thus constitute a tilted, nearly continuously exposed crustal section of the Mesozoic magmatic arc and framework rocks from subvolcanic levels to paleodepths as great as ??22 km. The base of this tilted arc section is a moderately east-dipping sheeted magmatic complex >10 km in width by 70 km in length, constructed structurally beneath, yet synchronous with Late Jurassic and Cretaceous upper-crustal plutons. Geochronology and regional structural relations thus suggest that arc magmas generated in the lower crust of this continental arc interacted in a complex mid-crustal zone of crystallization and mixing; products of this zone were parental magmas that formed relatively homogeneous upper crustal felsic plutons and fed lavas and voluminous ignimbrites. ?? 2009 The Geological Society of America.