| Abstract: | How genomic expression differs as a function of life history variation is largely unknown. Atlantic salmon exhibits extreme alternative life histories. We defined the gene-expression signatures of wild-caught salmon at two different life stages by comparing the brain expression profiles of mature sneaker males and immature males, and early migrants and late migrants. In addition to life-stage-specific signatures, we discovered a surprisingly large gene set that was differentially regulated-at similar magnitudes, yet in opposite direction-in both life history transitions. We suggest that this co-variation is not a consequence of many independent cellular and molecular switches in the same direction but rather represents the molecular equivalent of a physiological shift orchestrated by one or very few master regulators. ?? 2009 Elsevier Inc. All rights reserved. |
| Genre: | Article |
| ProdID: | 70036647 |
| Citation Author: | Aubin-Horth, N.; Letcher, B. H.; Hofmann, H. A. |
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| Citation End Page: | 284 |
| Citation Issue: | 3 |
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| Citation Language: | English |
| Citation Larger Work Title: | General and Comparative Endocrinology |
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| Citation Number Of Pages: | 7 |
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| Citation Search Results Text: | Gene-expression signatures of Atlantic salmon‘s plastic life cycle; 2009; Article; Journal; General and Comparative Endocrinology; Aubin-Horth, N.; Letcher, B. H.; Hofmann, H. A. |
| Citation Start Page: | 278 |
| Citation Volume: | 163 |
| Citation Year: | 2009 |
| Type: | citation/reference |
| Text: | Gene-expression signatures of Atlantic salmon‘s plastic life cycle; 2009; Article; Journal; General and Comparative Endocrinology; Aubin-Horth, N.; Letcher, B. H.; Hofmann, H. A. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| URL (DIGITAL OBJECT IDENTIFIER): | http://dx.doi.org/10.1016/j.ygcen.2009.04.021 |
| Date Other: | Thu, 1 Jan 2009 00:00 -0600 |
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