Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis)
Vaccine
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Abstract
In previous studies, we demonstrated protection against plague in mice and prairie dogs using a raccoon pox (RCN) virus-vectored vaccine that expressed the F1 capsular antigen of Yersinia pestis. In order to improve vaccine efficacy, we have now constructed additional RCN-plague vaccines containing two different forms of the lcrV (V) gene, including full-length (Vfull) and a truncated form (V307). Mouse challenge studies with Y. pestis strain CO92 showed that vaccination with a combination of RCN-F1 and the truncated V construct (RCN-V307) provided the greatest improvement (P = 0.01) in protection against plague over vaccination with RCN-F1 alone. This effect was mediated primarily by anti-F1 and anti-V antibodies and both contributed independently to increased survival of vaccinated mice.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis) |
| Series title | Vaccine |
| DOI | 10.1016/j.vaccine.2009.10.043 |
| Volume | 28 |
| Issue | 2 |
| Year Published | 2009 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | National Wildlife Health Center |
| Description | 7 p. |
| First page | 338 |
| Last page | 344 |
| Google Analytic Metrics | Metrics page |