| Abstract: | Losses from infectious diseases are an important component of natural mortality among marine fish species, but factors controlling the ecology of these diseases and their potential responses to anthropogenic changes are poorly understood. We used viral hemorrhagic septicemia virus (VHSV) and a laboratory stock of Pacific herring Clupea pallasii to investigate the kinetics of viral shedding and its effect on disease transmission and host mortality. Outbreaks of acute disease, accompanied by mortality and viral shedding, were initiated after waterborne exposure of herring to concentrations of VHSV as low as 10 1 plaque-forming units (pfu) ml-1. Shed virus in flow-through tanks was first detected 4 to 5 d post-exposure, peaked after 6 to 10 d, and was no longer detected after 16 d. Shedding rates, calculated from density, flow and waterborne virus titer reached 1.8 to 5.0 ?? ?10 8 pfu fish-1 d-1. Onset of viral shedding was dose-dependent and preceded initial mortality by 2 d. At 21 d, cumulative mortality in treatment groups ranged from 81 to 100% and was dependent not on challenge dose, but on the kinetics and level of viral shedding by infected fish in the tank. Possible consequences of the viral shedding and disease kinetics are discussed in the context of epizootic initiation and perpetuation among populations of wild Pacific herring. ?? Inter-Research 2010. |
| Genre: | Article |
| ProdID: | 70037267 |
| Citation Author: | Hershberger, P.; Gregg, J.; Grady, C.; Collins, R.; Winton, J. |
| Citation Contributing Office: | |
| Citation Datum: | |
| Citation Day: | |
| Citation Edition: | |
| Citation Editor: | |
| Citation End Page: | 193 |
| Citation Issue: | |
| Citation Keywords: | |
| Citation Language: | English |
| Citation Larger Work Title: | Marine Ecology Progress Series |
| Citation LatN: | |
| Citation LatS: | |
| Citation LonE: | |
| Citation LonW: | |
| Citation Month: | |
| Citation No Pagination: | |
| Citation Number Of Pages: | 7 |
| Citation Online Only Flag: | |
| Citation Phsyical Description: | |
| Citation Projection: | |
| Citation Public Comments: | |
| Citation Publisher: | |
| Citation Series: | |
| Citation Series Code: | |
| Citation Series Number: | |
| Citation Search Results Text: | Kinetics of viral shedding provide insights into the epidemiology of viral hemorrhagic septicemia in Pacific herring; 2010; Article; Journal; Marine Ecology Progress Series; Hershberger, P.; Gregg, J.; Grady, C.; Collins, R.; Winton, J. |
| Citation Start Page: | 187 |
| Citation Volume: | 400 |
| Citation Year: | 2010 |
| Type: | citation/reference |
| Text: | Kinetics of viral shedding provide insights into the epidemiology of viral hemorrhagic septicemia in Pacific herring; 2010; Article; Journal; Marine Ecology Progress Series; Hershberger, P.; Gregg, J.; Grady, C.; Collins, R.; Winton, J. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| URL (DIGITAL OBJECT IDENTIFIER): | http://dx.doi.org/10.3354/meps08420 |
| Date Other: | Fri, 1 Jan 2010 00:00 -0600 |
| Publisher: | |
