| Abstract: | The safety of Aquaflor® (50% w/w florfenicol [FFC]) incorporated in feed then administered to tilapia for 20 days (2x the recommended duration) at 0, 15, 45, or 75 mg/kg body weight/day (0, 1, 3, or 5x the recommended dose of 15 mg FFC/kg BW/d) was investigated. Mortality, behavioral change, feed consumption, body size, and gross and microscopic lesions were determined. Estimated delivered doses were >96.9% of target. Three unscheduled mortalities occurred but were considered incidental since FFC-related findings were not identified. Feed consumption was only affected during the last 10 dosing days when the 45 and 75 mg/kg groups consumed only 62.5% and 55.3% of the feed offered, respectively. There were significant, dose-dependent reductions in body size in the FFC-dose groups relative to the controls. Treatment-related histopathological findings included increased severity of lamellar epithelial hyperplasia, increased incidence of lamellar adhesions, decreased incidence of lamellar telangiectasis in the gills, increased glycogen-type and lipid-type hepatocellular vacuolation in the liver, decreased lymphocytes, increased blast cells, and increased individual cell necrosis in the anterior kidney, and tubular epithelial degeneration and mineralization in the posterior kidney. These changes are likely to be of minimal clinical relevance, given the lack of mortality or morbidity observed. This study has shown that FFC, when administered in feed to tilapia at the recommended dose (15 mg FFC/kg BW/day) for 10 days would be well tolerated. |
| Genre: | Article |
| ProdID: | 70040568 |
| Citation Author: | Gaikowski, Mark P.; Wolf, Jeffrey C.; Schleis, Susan M.; Tuomari, Darrell; Endris, Richard G. |
| Citation Contributing Office: | Upper Midwest Environmental Sciences Center |
| Citation Datum: | |
| Citation Day: | 26 |
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| Citation End Page: | 652 |
| Citation Issue: | 4 |
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| Citation Language: | English |
| Citation Larger Work Title: | Toxicologic Pathology |
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| Citation Month: | 10 |
| Citation No Pagination: | |
| Citation Number Of Pages: | 14 |
| Citation Online Only Flag: | |
| Citation Phsyical Description: | 14 p. |
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| Citation Publisher: | SAGE Publications |
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| Citation Search Results Text: | Safety of florfenicol administered in feed to tilapia (Oreochromis sp.); 2013; Article; Journal; Toxicologic Pathology; Gaikowski, Mark P.; Wolf, Jeffrey C.; Schleis, Susan M.; Tuomari, Darrell; Endris, Richard G. |
| Citation Start Page: | 639 |
| Citation Volume: | 41 |
| Citation Year: | 2013 |
| Type: | citation/reference |
| Text: | Safety of florfenicol administered in feed to tilapia (Oreochromis sp.); 2013; Article; Journal; Toxicologic Pathology; Gaikowski, Mark P.; Wolf, Jeffrey C.; Schleis, Susan M.; Tuomari, Darrell; Endris, Richard G. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| URL (DIGITAL OBJECT IDENTIFIER): | http://dx.doi.org/10.1177/0192623312463986 |
| Date Other: | Wed, 31 Oct 2012 00:00 -0500 |
| Publisher: | SAGE Publications |
