| Abstract: | Avian risk assessments for rodenticides are often driven by the results of standardized acute oral toxicity tests without regards to a toxicant‘s mode of action and time course of adverse effects. First generation anticoagulant rodenticides (FGARs) generally require multiple feedings over several days to achieve a threshold concentration in tissue and cause adverse effects. This exposure regimen is much different than that used in the standardized acute oral toxicity test methodology. Median lethal dose values derived from standardized acute oral toxicity tests underestimate the environmental hazard and risk of FGARs. Caution is warranted when FGAR toxicity, physiological effects, and pharmacokinetics derived from standardized acute oral toxicity testing are used for forensic confirmation of the cause of death in avian mortality incidents and when characterizing FGARs‘ risks to free-ranging birds. |
| Genre: | Article |
| ProdID: | 70040582 |
| Citation Author: | Vyas, Nimish B.; Rattner, Barnett A. |
| Citation Contributing Office: | Patuxent Wildlife Research Center |
| Citation Datum: | |
| Citation Day: | 27 |
| Citation Edition: | |
| Citation Editor: | |
| Citation End Page: | 1077 |
| Citation Issue: | 5 |
| Citation Keywords: | |
| Citation Language: | English |
| Citation Larger Work Title: | Human and Ecological Risk Assessment |
| Citation LatN: | |
| Citation LatS: | |
| Citation LonE: | |
| Citation LonW: | |
| Citation Month: | 9 |
| Citation No Pagination: | |
| Citation Number Of Pages: | 9 |
| Citation Online Only Flag: | |
| Citation Phsyical Description: | 9 p. |
| Citation Projection: | |
| Citation Public Comments: | |
| Citation Publisher: | Taylor & Francis |
| Citation Series: | |
| Citation Series Code: | |
| Citation Series Number: | |
| Citation Search Results Text: | Critique on the use of the standardized avian acute oral toxicity test for first generation anticoagulant rodenticides; 2012; Article; Journal; Human and Ecological Risk Assessment; Vyas, Nimish B.; Rattner, Barnett A. |
| Citation Start Page: | 1069 |
| Citation Volume: | 18 |
| Citation Year: | 2012 |
| Type: | citation/reference |
| Text: | Critique on the use of the standardized avian acute oral toxicity test for first generation anticoagulant rodenticides; 2012; Article; Journal; Human and Ecological Risk Assessment; Vyas, Nimish B.; Rattner, Barnett A. |
| URL (DIGITAL OBJECT IDENTIFIER): | http://dx.doi.org/10.1080/10807039.2012.707934 |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| Date Other: | Fri, 2 Nov 2012 00:00 -0500 |
| Publisher: | Taylor & Francis |
