| Abstract: | Viral haemorrhagic septicaemia virus (VHSV) and its associated disease state, viral haemorrhagic septicaemia (VHS), is hypothesized to be a proximate factor accounting for the decline and failed recovery of Pacific herring populations in Prince William Sound, AK (Marty et al. 1998, 2003, 2010). Survivors of laboratory-induced VHSV epizootics develop resistance to subsequent viral exposure (Kocan et al. 2001; Hershberger et al. 2007, 2010), which is likely the result of immune system recognition of the viral glycoprotein (G) (Lecocq-Xhonneux et al. 1994), a surface antigen that contains neutralizing epitopes (Lorenzen, Olesen & Jorgensen 1990; Jørgensen et al. 1995) and cell attachment domains (Lecocq-Xhonneux et al. 1994; Estepa & Coll 1996). These properties have proven useful in the development of G-gene-based DNA vaccines for VHSV and a related rhabdovirus, infectious haematopoietic necrosis virus (IHNV) (Anderson et al. 1996; Heppell et al. 1998; Corbeil et al. 1999; Einer-Jensen et al. 2009). Rainbow trout fingerlings, Oncorhynchus mykiss (Walbaum), vaccinated with 1 µg of either the VHS or IHN vaccine are protected from VHS when exposed to virus as early as 4 days (44 degree days) post-vaccination (p.v.) (Lorenzen et al. 2002). At later time points (80 days p.v.; 880 degree days), the level of cross-protection against VHS by IHN vaccination is either completely lost (60 days p.v.; 660 degree days) (3 g rainbow trout; 1 µg vaccine dose) (Lorenzen et al. 2002) or present at intermediate levels (6.5 g rainbow trout; 1 µg vaccine dose) (Einer-Jensen et al. 2009). Comparatively, VHS vaccination remains effective as long as 9 months (2520 degree days) p.v. (100 g rainbow trout; 0.5 µg vaccine dose) (McLauchlan et al. 2003). These results suggest that IHN and VHS vaccination activate a rapid transitory innate immune response against VHSV that is followed by long-term adaptive immunity in VHS-vaccinated trout (Lorenzen et al. 2002). |
| Genre: | Article |
| ProdID: | 70041088 |
| Citation Author: | Hart, L. M.; Lorenzen, Niels; LaPatra, S. E.; Grady, C. A.; Roon, S. E.; O’Reilly, J.; Gregg, J. L.; Hershberger, P. K. |
| Citation Contributing Office: | Western Fisheries Research Center |
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| Citation End Page: | 779 |
| Citation Issue: | 10 |
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| Citation Language: | English |
| Citation Larger Work Title: | Journal of Fish Diseases |
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| Citation Number Of Pages: | 4 |
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| Citation Phsyical Description: | 5 p. |
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| Citation Publisher: | Wiley |
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| Citation Search Results Text: | Efficacy of a glycoprotein DNA vaccine against viral haemorrhagic septicaemia (VHS) in Pacific herring, Clupea pallasii Valenciennes; 2012; Article; Journal; Journal of Fish Diseases; Hart, L. M.; Lorenzen, Niels; LaPatra, S. E.; Grady, C. A.; Roon, S. E.; O’Reilly, J.; Gregg, J. L.; Hershberger, P. K. |
| Citation Start Page: | 775 |
| Citation Volume: | 35 |
| Citation Year: | 2012 |
| Type: | citation/reference |
| Text: | Efficacy of a glycoprotein DNA vaccine against viral haemorrhagic septicaemia (VHS) in Pacific herring, Clupea pallasii Valenciennes; 2012; Article; Journal; Journal of Fish Diseases; Hart, L. M.; Lorenzen, Niels; LaPatra, S. E.; Grady, C. A.; Roon, S. E.; O’Reilly, J.; Gregg, J. L.; Hershberger, P. K. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| URL (DIGITAL OBJECT IDENTIFIER): | http://dx.doi.org/10.1111/j.1365-2761.2012.01364.x |
| Date Other: | Tue, 27 Nov 2012 00:00 -0600 |
| Publisher: | Wiley |
