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Viral fitness: definitions, measurement, and current insights

Current Opinion in Virology

By:
,
DOI: 10.1016/j.coviro.2012.07.007

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Abstract

Viral fitness is an active area of research, with recent work involving an expanded number of human, non-human vertebrate, invertebrate, plant, and bacterial viruses. Many publications deal with RNA viruses associated with major disease emergence events, such as HIV-1, influenza virus, and Dengue virus. Study topics include drug resistance, immune escape, viral emergence, host jumps, mutation effects, quasispecies diversity, and mathematical models of viral fitness. Important recent trends include increasing use of in vivo systems to assess vertebrate virus fitness, and a broadening of research beyond replicative fitness to also investigate transmission fitness and epidemiologic fitness. This is essential for a more integrated understanding of overall viral fitness, with implications for disease management in the future.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Viral fitness: definitions, measurement, and current insights
Series title:
Current Opinion in Virology
DOI:
10.1016/j.coviro.2012.07.007
Volume
2
Issue:
5
Year Published:
2012
Language:
English
Publisher:
Elsevier
Publisher location:
Amsterdam, Netherlands
Contributing office(s):
Western Fisheries Research Center
Description:
8 p.
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
First page:
538
Last page:
545
Number of Pages:
8
Country:
United States