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Worldwide phylogenetic relationship of avian poxviruses

Journal of Virology

By:
, , , , , , , , , , , , , , , , , , , and
DOI: 10.1128/​JVI.03183-12

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Abstract

Poxvirus infections have been found in 230 species of wild and domestic birds worldwide in both terrestrial and marine environments. This ubiquity raises the question of how infection has been transmitted and globally dispersed. We present a comprehensive global phylogeny of 111 novel poxvirus isolates in addition to all available sequences from GenBank. Phylogenetic analysis of Avipoxvirus genus has traditionally relied on one gene region (4b core protein). In this study we have expanded the analyses to include a second locus (DNA polymerase gene), allowing for a more robust phylogenetic framework, finer genetic resolution within specific groups and the detection of potential recombination. Our phylogenetic results reveal several major features of avipoxvirus evolution and ecology and propose an updated avipoxvirus taxonomy, including three novel subclades. The characterization of poxviruses from 57 species of birds in this study extends the current knowledge of their host range and provides the first evidence of the phylogenetic effect of genetic recombination of avipoxviruses. The repeated occurrence of avian family or order-specific grouping within certain clades (e.g. starling poxvirus, falcon poxvirus, raptor poxvirus, etc.) indicates a marked role of host adaptation, while the sharing of poxvirus species within prey-predator systems emphasizes the capacity for cross-species infection and limited host adaptation. Our study provides a broad and comprehensive phylogenetic analysis of the Avipoxvirus genus, an ecologically and environmentally important viral group, to formulate a genome sequencing strategy that will clarify avipoxvirus taxonomy.

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Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Worldwide phylogenetic relationship of avian poxviruses
Series title:
Journal of Virology
DOI:
10.1128/​JVI.03183-12
Volume
87
Issue:
9
Year Published:
2013
Language:
English
Publisher:
ASM Press
Publisher location:
Washington, D.C.
Contributing office(s):
National Wildlife Health Center
Description:
14 p.
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Journal of Virology
First page:
4938
Last page:
4951
Other Geospatial:
Worldwide
Online Only (Y/N):
N
Additional Online Files(Y/N):
N