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Expression kinetics of key genes in the early innate immune response to Great Lakes viral hemorrhagic septicemia virus IVb infection in yellow perch (Perca flavescens)

Developmental and Comparative Immunology

By:
, , , , ,
DOI: 10.1016/j.dci.2013.03.012

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Abstract

The recently discovered strain of viral hemorrhagic septicemia virus, VHSV-IVb, represents an example of the introduction of an extremely pathogenic rhabdovirus capable of infecting a wide variety of new fish species in a new host-environment. The goal of the present study was to delineate the expression kinetics of key genes in the innate immune response relative to the very early stages of VHSV-IVb infection using the yellow perch (Perca flavescens) as a model. Administration of VHSV-IVb by IP-injection into juvenile yellow perch resulted in 84% cumulative mortality, indicating their high susceptibility to this disease. In fish sampled in the very early stages of infection, a significant up-regulation of Mx gene expression in the liver, as well as IL-1β and SAA activation in the head kidney, spleen, and liver was directly correlated to viral load. The potential down-regulation of Mx in the hematopoietic tissues, head kidney and spleen, may represent a strategy utilized by the virus to increase replication.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Expression kinetics of key genes in the early innate immune response to Great Lakes viral hemorrhagic septicemia virus IVb infection in yellow perch (Perca flavescens)
Series title:
Developmental and Comparative Immunology
DOI:
10.1016/j.dci.2013.03.012
Volume
41
Issue:
1
Year Published:
2013
Language:
English
Publisher:
Elsevier
Contributing office(s):
Western Fisheries Research Center
Description:
9 p.
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
First page:
11
Last page:
19
Number of Pages:
9
Additional Online Files(Y/N):
N