Since the initial detection of Asian carp moving up the Mississippi Basin, the potential for invasion of the Great Lakes by Silver Carp and Bighead Carp has been a major concern to stakeholders. To combat this problem, sampling for environmental DNA (eDNA) is used to monitor the waterways near Lake Michigan. This monitoring area includes the Chicago Area Waterways System (CAWS) and the Des Plaines River. By sampling waters that may be inhabited by Asian carp, the extraction and amplification of carp DNA from the collected cellular debris is possible. This technique has been successfully used in several other contexts (Ficetola et al., 2008; Foote et al., 2008) and is believed to be a highly sensitive method for species detection (Dejean et al., 2012). Compared to traditional methods for surveying aquatic invasive species (fishing, rotenone application, and electrofishing), the increased sensitivity of this method could be a valuable asset. Early detection could lead to a more rapid response to the threat of a Great Lakes invasion by Asian carp.