Determination of Antimycin-A in water by liquid chromatographic/mass spectrometry: single-laboratory validation
Journal of AOAC International
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Abstract
An LC/MS method was developed and validated for the quantitative determination and confirmation of antimycin-A (ANT-A) in water from lakes or streams. Three different water sample volumes (25, 50, and 250 mL) were evaluated. ANT-A was stabilized in the field by immediately extracting it from water into anhydrous acetone using SPE. The stabilized concentrated samples were then transported to a laboratory and analyzed by LC/MS using negative electrospray ionization. The method was determined to have adequate accuracy (78 to 113% recovery), precision (0.77 to 7.5% RSD with samples ≥500 ng/L and 4.8 to 17% RSD with samples ≤100 ng/L), linearity, and robustness over an LOQ range from 8 to 51 600 ng/L.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Determination of Antimycin-A in water by liquid chromatographic/mass spectrometry: single-laboratory validation |
| Series title | Journal of AOAC International |
| DOI | 10.5740/jaoacint.12-286 |
| Edition | 2 |
| Volume | 96 |
| Year Published | 2013 |
| Language | English |
| Publisher | Association of Analytical Communities (AOAC) International |
| Contributing office(s) | Upper Midwest Environmental Sciences Center |
| Description | 9 p. |
| First page | 413 |
| Last page | 421 |
| Online Only (Y/N) | N |
| Additional Online Files (Y/N) | N |
| Google Analytic Metrics | Metrics page |