Tolazoline reversal of xylazine in bison (Bison bison): Mitigation of adverse effects
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Abstract
Tolazoline is a mixed alpha-1 and -2 adrenergic antagonist used to reverse the sedative, analgesic and muscle-relaxing effects of xylazine, a potent alpha adrenergic agonist. Tolazoline has been used in cattle and is superior to yohimbine, another alpha adrenergic antagonist, in this species. In white-tailed deer, tolazoline shortened recovery times and reversed xylazine-induced bradycardia, respiratory depression, and bloat following xylazine-ketamine anesthesia (Kreeger et al. 1986). We have used it for a number of years in moose without any detected adverse reactions. Caulkett et al. (2000) used tolazoline in wood bison to reverse the xylazine-induced effects of xylazine-tiletamine/zolazepam anesthesia and did not report any ill effects. However, the reported side effects of tolazoline in horses (species for which the drug was developed and is labeled) include abdominal discomfort, gastrointestinal hypermotility, diarrhea, tachycardia, ventricular dysrhythmia, hypertension and apprehensiveness.
| Publication type | Conference Paper |
|---|---|
| Publication Subtype | Conference Paper |
| Title | Tolazoline reversal of xylazine in bison (Bison bison): Mitigation of adverse effects |
| Year Published | 2002 |
| Language | English |
| Publisher | Wildlife Disease Association |
| Contributing office(s) | Northern Rocky Mountain Science Center |
| Description | 2 p. |
| First page | 142 |
| Last page | 143 |
| Conference Title | 51st Annual Wildlife Disease Association Conference |
| Conference Location | Arcata, CA |
| Conference Date | July 28-August 1, 2002 |
| Online Only (Y/N) | N |
| Additional Online Files (Y/N) | N |
| Google Analytic Metrics | Metrics page |