Effects of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) injected into the yolks of chicken (Gallus domesticus) eggs prior to incubation

D.C. Powell; R.J. Aulerich; J.C. Meadows; D. E. Tillitt; J. P. Giesy; K. L. Stromborg; S.J. Bursian

doi:10.1007/BF00212680

Effects of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) injected into the yolks of chicken (Gallus domesticus) eggs prior to incubation

Archives of Environmental Contamination and Toxicology

By: D.C. Powell, R.J. Aulerich, J.C. Meadows, D. E. Tillitt, J. P. Giesy, K. L. Stromborg, and S.J. Bursian

https://doi.org/10.1007/BF00212680

Links

More information: Publisher Index Page (via DOI)
Download citation as: RIS | Dublin Core

Abstract

The yolks of White Leghorn chicken (Gallus domesticus) eggs were injected prior to incubation with either 3,3′,4,4′,5- pentachlorobiphenyl (PCB 126) at doses ranging from 0.1 to 12.8 μg/kg egg or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at doses ranging from 0.04 to 0.64 μg/kg egg. Chicks were subjected to necropsy within 24 h of hatching. The brain, bursa, heart, liver, and spleen were removed and weighed. Assessment of the rate of hatching indicated an LD₅₀±S.E. of 2.3±0.19 μg/kg egg (7.1±0.58 nmol/kg egg) for PCB 126 and 0.15±0.012 μg/kg egg (0.47±0.037 nmol/kg egg) for TCDD. No significant differences in the incidence of developmental abnormalities (structural defects and edema) were observed in TCDD-exposed embryos, while PCB 126 caused significantly more developmental abnormalities at 3.2, 6.4, and 12.8 μg/kg egg than the vehicle control. PCB 126 caused lower hatchling weights and greater relative brain, heart, and liver weights when compared to the vehicle control group at a dose of 3.2 μg/kg egg which is greater than the LD₅₀. TCDD at 0.08 μg/kg egg caused relative bursa weights to be less than those of the vehicle control. A toxic equivalency factor (TEF) of 0.07 was determined for PCB 126 in relation to TCDD based on overt lethality.

Additional publication details
Publication type	Article
Publication Subtype	Journal Article
Title	Effects of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) injected into the yolks of chicken (Gallus domesticus) eggs prior to incubation
Series title	Archives of Environmental Contamination and Toxicology
DOI	10.1007/BF00212680
Volume	31
Year Published	1996
Language	English
Publisher	Springer
Contributing office(s)	Columbia Environmental Research Center
Description	6 p.
First page	404
Last page	409
Google Analytic Metrics	Metrics page