Located near the triple junction of the African, Arabia, and Eurasian Plate, Cyprus has had an active and complex neotectonic history, which includes devastating historical earthquakes. Investigations into the tectonic framework of the northern part of Cyprus provide important insights into regional tectonism of the Eastern Mediterranean and Middle East. The northern part of Cyprus is divided into two tectono-stratigraphic terranes, the boundary of which is the Ovgos fault zone. In the Middle Miocene, the Ovgos fault zone was a marine platform margin, which separated open-marine platform carbonates from deep-marine turbidites. Transpressive movement along easterly and northeasterly trending structures dominated the Late Miocene; deposition and preservation of Messinian evaporites occurred in grabens at intersections of these trends. N–S compression began in the Early Pliocene and produced contractional tectonism along east–west trends, including major thrusting of allochthonous rocks in the Kyrenia Range. Quaternary deformation has been dominated by strike-slip faults along northeast and northwest trends; movement during the Pleistocene occurred on several of these faults; Holocene movement is documented on one of these faults. A seismic hazard is implied for the Nicosia area because its proximity to the Quaternary faults. Since the Miocene, Cyprus has been continuously uplifted, but the tectonic setting is controversial, as some researchers invoke a subduction zone setting and others ascribe to a regime of strike-slip tectonics. Our neotectonic framework is consistent with a restraining bend model for Cyprus in a regional strike-slip regime.