A wide variety of human activities have the potential to contaminate groundwater. In addition, naturally occurring constituents can limit the suitability of groundwater for some uses. The State of Wyoming has established rules and programs to evaluate and protect groundwater quality based on identified uses. The Wyoming Groundwater-Quality Monitoring Network (WGQMN) is a cooperative program between the U.S. Geological Survey (USGS) and the Wyoming Department of Environmental Quality (WDEQ) and was implemented in 2009 to evaluate the water-quality characteristics of the State's groundwater. Representatives from USGS, WDEQ, U.S. Environmental Protection Agency (USEPA), Wyoming Water Development Office, and Wyoming State Engineer's Office formed a steering committee, which meets periodically to evaluate progress and consider modifications to strengthen program objectives. The purpose of this fact sheet is to describe the WGQMN design and objectives, field procedures, and water-quality analyses. USGS groundwater activities in the Greater Green River Basin also are described.