This fact sheet summarizes the multifaceted research of the U.S. Geological Survey—published in diverse outlets—that focuses on the subaqueous cavern Devils Hole in Nevada. Questions addressed in the fact sheet are: What is Devils Hole? Why is Devils Hole of interest to paleoclimatologists? How was the isotopic record from the Devils Hole vein calcite dated? What paleoclimate phenomena are recorded by the Devils Hole stable isotopic time series? Where can one find the isotopic records? What contributions has Devils Hole research made to the field of paleoclimatology, paleohydrology, and geochemistry? What does Devils Hole reveal about how long we can expect the present interglaciation to last? What are some practical applications of the Devils Hole findings? Why is Devils Hole of interest to zoologists?