The Mississippi Embayment aquifer system is composed of six regional aquifers covering about 160,000 square miles in parts of Alabama, Arkansas, Illinois, Kentucky, Louisiana, Mississippi, Missouri, and Tennessee. The flow analysis presented in this report as part of the Gulf Coast Regional Aquifer-System Analysis study pertains to five aquifers in sediments of the Wilcox and Claiborne groups of Tertiary age. In descending order, the aquifers are (1) the upper Claiborne, (2) the middle Claiborne, (3) the lower Claiborne-upper Wilcox, (4) the middle Wilcox, and (5) the lower Wilcox. The flow analysis of the sixth aquifer in the aquifer system, the Mississippi River valley alluvial aquifer in sediments of Holocene and Pleistocene age, is presented in chapter D of this Professional Paper.