The U.S. Geological Survey, in cooperation with the Mississippi Department of Environmental Quality, Office of Land and Water Resources, and the Natural Resources Conservation Service, estimated the volumetric changes of water in the Mississippi River alluvial aquifer in northwestern Mississippi from 1980 through 1994. Volumetric changes of water in the alluvial aquifer were estimated for the entire Delta and for five selected areas within the Delta. The volume of water per square mile in the alluvial aquifer in the Delta changed from 17,886 acre-feet during fall 1980 to 17,719 acre-feet during fall 1994, a decrease in volume per square mile of 167 acre-feet. The minimum volume of water per square mile in the alluvial aquifer in the Delta during 1980-94 was 17,640 acre-feet during fall 1988. Of five selected areas within the Delta, an area near Cleveland in Bolivar County had the greatest change in volume of water in the alluvial aquifer. During fall 1980 this area had 20,790 acre-feet of water per square mile in the aquifer; by fall 1994, the volume had decreased to 19,947 acre-feet of water per square mile. An area located in the vicinity of the Sunflower-Leflore County line has within its boundaries a large cone of depression in the potentiometric surface of the alluvial aquifer. The volume of water per square mile in this area decreased from 17,857 acre-feet during fall 1980 to 17,075 acre-feet during fall 1994.