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Liquid chromatographic determination of florfenicol in the plasma of multiple species of fish

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
By: , and 

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Abstract

A simple method was developed for determining florfenicol concentration in a small volume (250 mul) of plasma from five phylogenetically diverse species of freshwater fish. Florfenicol was isolated from the plasma matrix through C-18 solid-phase extraction and quantified by reversed-phase high-performance liquid chromatography with UV detection. The accuracy (84-104%), precision (%RSDless than or equal to8), and sensitivity (quantitation limit <30 ng/ml) of the method indicate its usefulness for conducting pharmacokinetic studies on a variety of freshwater fish. Published by Elsevier Science B.V.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Liquid chromatographic determination of florfenicol in the plasma of multiple species of fish
Series title Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume 780
Issue 1
Year Published 2002
Language English
Publisher U.S. Geological Survey
Contributing office(s) Upper Midwest Environmental Sciences Center
Description pp. 111-117
Larger Work Type Article
Larger Work Subtype Journal Article
Larger Work Title Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
First page 111
Last page 117