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Disposition of 1-naphthol in the channel catfish (Ictalurus punctatus)

Drug Metabolism and Disposition
By:  and 

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Abstract

The pharmacokinetics, tissue distribution, and metabolism of 1-naphthol were examined in the channel catfish (Ictalurus punctatus ). After oral dosing, peak plasma concentrations of 1-naphthol occurred at 1 hr; parent compound made up less than 15% of the total radioactivity, and the bioavailability was 32%. Plasma protein binding was 92% and was independent of concentration. 1-Naphthol and metabolites were rapidly eliminated from the tissues after oral dosing.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Disposition of 1-naphthol in the channel catfish (Ictalurus punctatus)
Series title Drug Metabolism and Disposition
Volume 20
Issue 1
Year Published 1992
Language English
Publisher U.S. Food and Drug Administration
Publisher location Dauphin Island, AL
Contributing office(s) Upper Midwest Environmental Sciences Center
Description pp. 70-73
Larger Work Type Article
Larger Work Subtype Journal Article
Larger Work Title Drug Metabolism and Disposition
First page 70
Last page 73
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