Pharmacokinetics of gentamicin in blood plasma of quail, pheasants, and cranes
American Journal of Veterinary Research
By: R.S. Custer, M. Bush, and J. W. Carpenter
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Abstract
Rate of appearance, peak concentration, and the biological half-life of gentamicin in the plasma of quail (Coturnix coturnix), pheasants (Phasianus colchicus), and cranes (Grus canadensis tabida) were studied. Gentamicin was given IM in doses of 5, 10, and 20 mg/kg of body weight. Peak plasma concentrations occurred earliest in the quail, latest in the cranes. The peak concentrations varied directly with the administered doses in all species. The biological half-life of gentamicin was 42 +/- 12 minutes in the quail, 75 +/- 15 minutes in the pheasants, and 165 +/- 37 minutes in the cranes. On the basis of the present data, dosage regimens for gentaminic of 5 mg/kg every 8 hours in pheasants and cranes, and 10 mg/kg every 6 hours in quail, would be expected to give constant plasma concentrations greater than 4.0 micrograms/ml.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Pharmacokinetics of gentamicin in blood plasma of quail, pheasants, and cranes |
| Series title | American Journal of Veterinary Research |
| Volume | 40 |
| Issue | 6 |
| Year Published | 1979 |
| Language | English |
| Contributing office(s) | Patuxent Wildlife Research Center |
| Description | 892-895 |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | American Journal of Veterinary Research |
| First page | 892 |
| Last page | 895 |
| Google Analytic Metrics | Metrics page |