Depression of plasma luteinizing hormone concentration in quail by the anticholinesterase insecticide parathion
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Abstract
1. To examine the effects of parathion on basal plasma luteinizing hormone (LH) concentration, male Japanese quail (Coturnix japonica) were orally intubated with 0, 5 or 10 mg/kg parathion and sacrificed after 4, 8 and 24 hr.
2. At the 5 mg/kg dose, plasma LH levels were reduced at 4 and 8 hr, but returned to control values by 24 hr. Brain acetylcholinesterase activity was substantially reduced by 10 mg/kg parathion (52, 75 and 37% inhibition at 4, 8 and 24 hr, respectively) and plasma LH concentration remained depressed through the 24-hr period.
3. These findings suggest that the organophosphorus insecticide parathion may alter plasma LH concentration in a manner which might impair reproductive activity, and provide indirect evidence for a cholinergic component in the regulation of LH secretion in quail.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Depression of plasma luteinizing hormone concentration in quail by the anticholinesterase insecticide parathion |
| Series title | Comparative Biochemistry and Physiology, Part C: Comparative Pharmacology |
| DOI | 10.1016/0742-8413(86)90153-2 |
| Volume | 83 |
| Issue | 2 |
| Year Published | 1986 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | Patuxent Wildlife Research Center |
| Description | 3 p. |
| First page | 451 |
| Last page | 453 |
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