Depression of plasma luteinizing hormone concentration in quail by the anticholinesterase insecticide parathion

Comparative Biochemistry and Physiology, Part C: Comparative Pharmacology
By: , and 

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Abstract

1. To examine the effects of parathion on basal plasma luteinizing hormone (LH) concentration, male Japanese quail (Coturnix japonica) were orally intubated with 0, 5 or 10 mg/kg parathion and sacrificed after 4, 8 and 24 hr.

2. At the 5 mg/kg dose, plasma LH levels were reduced at 4 and 8 hr, but returned to control values by 24 hr. Brain acetylcholinesterase activity was substantially reduced by 10 mg/kg parathion (52, 75 and 37% inhibition at 4, 8 and 24 hr, respectively) and plasma LH concentration remained depressed through the 24-hr period.

3. These findings suggest that the organophosphorus insecticide parathion may alter plasma LH concentration in a manner which might impair reproductive activity, and provide indirect evidence for a cholinergic component in the regulation of LH secretion in quail.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Depression of plasma luteinizing hormone concentration in quail by the anticholinesterase insecticide parathion
Series title Comparative Biochemistry and Physiology, Part C: Comparative Pharmacology
DOI 10.1016/0742-8413(86)90153-2
Volume 83
Issue 2
Year Published 1986
Language English
Publisher Elsevier
Contributing office(s) Patuxent Wildlife Research Center
Description 3 p.
First page 451
Last page 453