Depression of plasma luteinizing hormone concentration in quail by the anticholinesterase insecticide parathion
Comparative Biochemistry and Physiology, Part C: Comparative Pharmacology
- B.A. Rattner, R.N. Clarke, and M.A. Ottinger
1. To examine the effects of parathion on basal plasma luteinizing hormone (LH) concentration, male Japanese quail (Coturnix japonica) were orally intubated with 0, 5 or 10 mg/kg parathion and sacrificed after 4, 8 and 24 hr.
2. At the 5 mg/kg dose, plasma LH levels were reduced at 4 and 8 hr, but returned to control values by 24 hr. Brain acetylcholinesterase activity was substantially reduced by 10 mg/kg parathion (52, 75 and 37% inhibition at 4, 8 and 24 hr, respectively) and plasma LH concentration remained depressed through the 24-hr period.
3. These findings suggest that the organophosphorus insecticide parathion may alter plasma LH concentration in a manner which might impair reproductive activity, and provide indirect evidence for a cholinergic component in the regulation of LH secretion in quail.
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- Publication type:
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- Journal Article
- Depression of plasma luteinizing hormone concentration in quail by the anticholinesterase insecticide parathion
- Series title:
- Comparative Biochemistry and Physiology, Part C: Comparative Pharmacology
- Year Published:
- Contributing office(s):
- Patuxent Wildlife Research Center
- 3 p.
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