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Depression of plasma luteinizing hormone concentration in quail by the anticholinesterase insecticide parathion

Comparative Biochemistry and Physiology, Part C: Comparative Pharmacology

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, , and
https://doi.org/10.1016/0742-8413(86)90153-2

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Abstract

1. To examine the effects of parathion on basal plasma luteinizing hormone (LH) concentration, male Japanese quail (Coturnix japonica) were orally intubated with 0, 5 or 10 mg/kg parathion and sacrificed after 4, 8 and 24 hr.

2. At the 5 mg/kg dose, plasma LH levels were reduced at 4 and 8 hr, but returned to control values by 24 hr. Brain acetylcholinesterase activity was substantially reduced by 10 mg/kg parathion (52, 75 and 37% inhibition at 4, 8 and 24 hr, respectively) and plasma LH concentration remained depressed through the 24-hr period.

3. These findings suggest that the organophosphorus insecticide parathion may alter plasma LH concentration in a manner which might impair reproductive activity, and provide indirect evidence for a cholinergic component in the regulation of LH secretion in quail.

Additional publication details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Depression of plasma luteinizing hormone concentration in quail by the anticholinesterase insecticide parathion
Series title:
Comparative Biochemistry and Physiology, Part C: Comparative Pharmacology
DOI:
10.1016/0742-8413(86)90153-2
Volume:
83
Issue:
2
Year Published:
1986
Language:
English
Publisher:
Elsevier
Contributing office(s):
Patuxent Wildlife Research Center
Description:
3 p.
First page:
451
Last page:
453