Use of mixed-function oxygenases to monitor contaminant exposure in wildlife

Environmental Toxicology and Chemistry
By: , and 



This overview examines the utility of mixed-function oxygenase (MFO) enzymes as a bioeffects monitor for wildlife (amphibians, reptiles, birds and mammals) in view of their widespread use as indicators of contaminant exposure in aquatic invertebrates and fish. Phylogenetic trends in MFO activity, toxicological implications of induction and the relationship between contaminant exposure and MFO activity are discussed. Field studies using avian embryos and hatchlings suggest that MFO induction has utility for documenting contaminant exposure; however, findings in adult birds and mammals are equivocal. Age, sex and season are sources of variation that require consideration when undertaking field trials. Further understanding of MFO inducibility among species and application of recently developed analytical techniques including quantification of specific cytochrome P-450 isozymes are warranted.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Use of mixed-function oxygenases to monitor contaminant exposure in wildlife
Series title Environmental Toxicology and Chemistry
DOI 10.1002/etc.5620081202
Volume 8
Issue 12
Year Published 1989
Language English
Publisher Society of Environmental Toxicology and Chemistry
Contributing office(s) Patuxent Wildlife Research Center
Description 10 p.
First page 1093
Last page 1102
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