Thorough mixing of piscicides into receiving waters is important for efficient and effective fish eradication. However, no guidance exists for the placement of drip stations with respect to mixing. Salt (NaCl) was used as a tracer to measure the mixing rates of center versus edge applications in riffle–pool, straight, and meandering sections of montane streams. The tracer was applied at either the center or the edge of a channel and measured with a conductivity meter across a downstream grid to determine the distances at which transverse mixing was complete. No advantage was accrued by applying piscicides in different types of channels because transverse mixing distance did not differ among them. However, mixing distance was significantly shorter at center applications. Chemicals entering a stream at the center of the channel mixed thoroughly within 10 stream widths, whereas chemicals entering a stream channel at the edge mixed thoroughly within 20 stream widths.