Loess accumulated on a Bull Lake outwash terrace of Marine Oxygen Isotope Stage 6 (MIS 6) age in southern Jackson Hole, Wyoming. The 9 m section displays eight intervals of loess deposition (Loess 1 to Loess 8, oldest), each followed by soil development. Our age-depth model is constrained by thermoluminescence, meteoric Be-10 accumulation in soils, and cosmogenic Be-10 surface exposure ages. We use particle size, geochemical, mineral-magnetic, and clay mineralogical data to interpret loess sources and pedogenesis. Deposition of MIS 6 loess was followed by a tripartite soil/thin loess complex (Soils 8,7, and 6) apparently reflecting the large climatic oscillations of MIS 5. Soil 8 (MIS 5e) shows the strongest development. Loess 5 accumulated during a glacial interval (similar to 76-69 ka; MIS 4) followed by soil development under conditions wetter and probably colder than present. Deposition of thick Loess 3 (similar to 43-51 ka, MIS 3) was followed by soil development comparable with that observed in Soil 1. Loess 1 (MIS 2) accumulated during the Pinedale glaciation and was followed by development of Soil 1 under a semiarid climate. This record of alternating loess deposition and soil development is compatible with the history of Yellowstone vegetation and the glacial flour record from the Sierra Nevada. Published by Elsevier Inc. on behalf of University of Washington.