Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system

Bulletin of Environmental Contamination and Toxicology
By: , and 

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Abstract

Diphenhydramine hydrochloride (DH; Benadryl(TM), an over-the-counter antihistamine) and erythromycin thiocyanate (ET; a commonly used macrolide antibiotic) are pharmaceutical compounds whose chronic toxicity to Daphnia magna had not been characterized. Continuous exposure to DH concentrations about 5 times greater than the maximum reported environmental concentration of 0.023 μg/L for 21 days or to ET concentrations about 40 times the maximum reported environmental concentration of 6 μg/L for 21 days did not significantly impact D. magna survival and production. In this study the no observable effect concentration for DH was 0.12 μg/L and for ET was 248 μg/L.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system
Series title Bulletin of Environmental Contamination and Toxicology
Volume 85
Issue 5
Year Published 2011
Language English
Publisher Springer
Publisher location Amsterdam, Netherlands
Contributing office(s) Upper Midwest Environmental Sciences Center
Description 5 p.
Larger Work Type Article
Larger Work Subtype Journal Article
Larger Work Title Bulletin of Environmental Contamination and Toxicology
First page 447
Last page 451