Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system

Bulletin of Environmental Contamination and Toxicology
By: , and 

Links

Abstract

Diphenhydramine hydrochloride (DH; Benadryl(TM), an over-the-counter antihistamine) and erythromycin thiocyanate (ET; a commonly used macrolide antibiotic) are pharmaceutical compounds whose chronic toxicity to Daphnia magna had not been characterized. Continuous exposure to DH concentrations about 5 times greater than the maximum reported environmental concentration of 0.023 μg/L for 21 days or to ET concentrations about 40 times the maximum reported environmental concentration of 6 μg/L for 21 days did not significantly impact D. magna survival and production. In this study the no observable effect concentration for DH was 0.12 μg/L and for ET was 248 μg/L.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system
Series title Bulletin of Environmental Contamination and Toxicology
Volume 85
Issue 5
Year Published 2011
Language English
Publisher Springer
Publisher location Amsterdam, Netherlands
Contributing office(s) Upper Midwest Environmental Sciences Center
Description 5 p.
Larger Work Type Article
Larger Work Subtype Journal Article
Larger Work Title Bulletin of Environmental Contamination and Toxicology
First page 447
Last page 451
Google Analytic Metrics Metrics page
Additional metadata about this publication, not found in other parts of the page is in this table