18O, D, and H2O+ contents were measured for whole-rock specimens of granitoid rocks from 131 localitics in California and southwestern Oregon. With 41 new determinations in the Klamath Mountains and Sierra Nevada, initial strontium isotope ratios are known for 104 of these samples. Large variations in ??18O (5.5 to 12.4), ??D (-130 to -31), water contents (0.14 to 2.23 weight percent) and initial strontium isotope ratios (0.7028 to 0.7095) suggest a variety of source materials and identify rocks modified by secondary processes. Regular patterns of variation in each isotopic ratio exist over large geographical regions, but correlations between the ratios are generally absent except in restricted areas. For example, the regular decrease in ??D values from west to east in the Sierra Nevada batholith is not correlative with a quite complex pattern of ??18O values, implying that different processes were responsible for the isotopic variations in these two elements. In marked contrast to a good correlation between (87Sr/86Sr)o and ??18O observed in the Peninsular Ranges batholith to the south, such correlations are lacking except in a few areas. ??D values, on the other hand, correlate well with rock types, chemistry, and (87Sr/86Sr)o except in the Coast Ranges where few of the isotopic signatures are primary. The uniformly low ??D values of samples from the Mojave Desert indicate that meteoric water contributed much of the hydrogen to the rocks in that area. Even so, the ??18O values and 18O fractionations between quartz and feldspar are normal in these same rocks. This reconnaissance study has identified regularities in geochemical parameters over enormous geographical regions. These patterns are not well understood but merit more detailed examination because they contain information critical to our understanding of the development of granitoid batholiths. ?? 1981 Springer-Verlag.