The Piney Creek Wilderness in southwest Missouri was investigated by geologic, geochemical, and mineral-occurrence surveys. These is no evidence of metallic mineral deposits in the rock units exposed at the surface in the wilderness, but the entire area has a probable potential for significant zinc-lead deposits at depths of several hundred feet. A probable potential also exists for a small to moderate-sized iron ore deposit at a depth of at least 2100 ft along the northwest side of the wilderness. Evaluation of these potentials would require deep drilling, and in the case of the possible iron ore deposit, a detailed magnetic survey. No energy resource potential was identified within this area.