A technique to locate automatically boundaries between crustal blocks of disparate densities was applied to upward continued isostatic residual gravity data. The boundary analysis delineates a narrow gravitational trough that extends the length of the Pliocene and Quaternary volcanic arc from Mount Baker in northern Washington to Lassen Peak in California. Gravitational highs interrupt the trough at two localities: a northwest trending high in southern Washington and a northeast trending high between Mount Shasta and Lassen Peak. The gravity sources may reflect upper crustal structures older than the High Cascades, possibly relicts from earlier accretionary events or more recent crustal deformation, that have actively influenced the spatial location of more recent volcanism. Much of the Pliocene and Quaternary volcanism of the Cascade arc has concentrated on or near contacts between crustal blocks of disparate density. These contacts may promote the ascension of magma to the Earth's surface. -from Authors