The Sheraton - Universal hotel, an instrumented building lying in North Hollywood, USA is selected for case study in this paper. The finite element method is used to produce a linear time - invariant structural model, and the SAP2000 program is employed for the time history analysis of the instrumented structure under the base excitation of strong motions recorded in the basement during the Northridge, California earthquake of 17 January 1994. The calculated structural responses are compared with the recorded data in both time domain and frequency domain, and the effects of structural parameters evaluation and indeterminate factors are discussed. Some features of structural response, such as the reason why the peak responses of acceleration in the ninth floor are larger than those in the sixteenth floor, are also explained.