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High doses of corticosteroid suppress resistance to Ichthyophonus in starry flounder

Journal of Aquatic Animal Health
By: , and 

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Abstract

Application of pharmacological doses of the corticosteroid dexamethasone phosphate to starry flounder Platichthys stellatus resulted in a predisposition to clinical ichthyophoniasis and a progression from latent Ichthyophonus infections to patent, histologically identifiable infections. Among Ichthyophonus-challenged starry flounder, the prevalences of clinical infections and histologically identifiable infections were significantly greater in two groups that received dexamethasone (100% and 31%, respectively) than in the respective control groups (8% and 0%). Proliferation of Ichthyophonus infections in corticosteroid-treated groups may have resulted from suppression of the cellular immune response that typically follows corticosteroid application; however, further studies are needed to determine whether these effects occur at lower, physiological concentrations of corticosteroids.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title High doses of corticosteroid suppress resistance to Ichthyophonus in starry flounder
Series title Journal of Aquatic Animal Health
Volume 16
Issue 1
Year Published 2004
Language English
Contributing office(s) Western Fisheries Research Center
Description 5 p.
First page 45
Last page 49
Online Only (Y/N) N
Additional Online Files (Y/N) N