High doses of corticosteroid suppress resistance to Ichthyophonus in starry flounder
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Abstract
Application of pharmacological doses of the corticosteroid dexamethasone phosphate to starry flounder Platichthys stellatus resulted in a predisposition to clinical ichthyophoniasis and a progression from latent Ichthyophonus infections to patent, histologically identifiable infections. Among Ichthyophonus-challenged starry flounder, the prevalences of clinical infections and histologically identifiable infections were significantly greater in two groups that received dexamethasone (100% and 31%, respectively) than in the respective control groups (8% and 0%). Proliferation of Ichthyophonus infections in corticosteroid-treated groups may have resulted from suppression of the cellular immune response that typically follows corticosteroid application; however, further studies are needed to determine whether these effects occur at lower, physiological concentrations of corticosteroids.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | High doses of corticosteroid suppress resistance to Ichthyophonus in starry flounder |
| Series title | Journal of Aquatic Animal Health |
| DOI | 10.1577/H03-056.1 |
| Volume | 16 |
| Issue | 1 |
| Year Published | 2004 |
| Language | English |
| Publisher | Taylor & Francis Online |
| Contributing office(s) | Western Fisheries Research Center |
| Description | 5 p. |
| First page | 45 |
| Last page | 49 |
| Online Only (Y/N) | N |
| Additional Online Files (Y/N) | N |
| Google Analytic Metrics | Metrics page |