Evolutionary history of the ABCB2 genomic region in teleosts

Developmental and Comparative Immunology
By: , and 



Gene duplication, silencing and translocation have all been implicated in shaping the unique genomic architecture of the teleost MH regions. Previously, we demonstrated that trout possess five unlinked regions encoding MH genes. One of these regions harbors ABCB2 which in all other vertebrate classes is found in the MHC class II region. In this study, we sequenced a BAC contig for the trout ABCB2 region. Analysis of this region revealed the presence of genes homologous to those located in the human class II (ABCB2, BRD2, ??DAA), extended class II (RGL2, PHF1, SYGP1) and class III (PBX2, Notch-L) regions. The organization and syntenic relationships of this region were then compared to similar regions in humans, Tetraodon and zebrafish to learn more about the evolutionary history of this region. Our analysis indicates that this region was generated during the teleost-specific duplication event while also providing insight about potential MH paralogous regions in teleosts. ?? 2006 Elsevier Ltd. All rights reserved.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Evolutionary history of the ABCB2 genomic region in teleosts
Series title Developmental and Comparative Immunology
DOI 10.1016/j.dci.2006.07.010
Volume 31
Issue 5
Year Published 2007
Language English
Larger Work Type Article
Larger Work Subtype Journal Article
Larger Work Title Developmental and Comparative Immunology
First page 483
Last page 498