Chronic toxicity of erythromycin thiocyanate to Daphnia magna in a flow-through, continuous exposure test system

Bulletin of Environmental Contamination and Toxicology
By: , and 

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Abstract

Approval of a new animal drug application for AQUAMYCIN 100?? (erythromycin thiocyanate; ET) to treat freshwater salmonid species with bacterial kidney disease is being pursued in the US. As part of the approval process, ETs impact on an aquatic environment had to be described in an environmental assessment. The environmental assessment was lacking data to characterize the effect ET would have on a chronically exposed aquatic invertebrate organism. A major step to fulfilling the environmental assessment was completed after conducting a comprehensive study continuously exposing Daphnia magna to ET for 21 days. Results indicated that the no observable effect concentration for ET was 179 ??g/L. ?? 2011 Springer Science+Business Media, LLC (outside the USA).

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Chronic toxicity of erythromycin thiocyanate to Daphnia magna in a flow-through, continuous exposure test system
Series title Bulletin of Environmental Contamination and Toxicology
DOI 10.1007/s00128-011-0415-8
Volume 87
Issue 6
Year Published 2011
Language English
Larger Work Type Article
Larger Work Subtype Journal Article
Larger Work Title Bulletin of Environmental Contamination and Toxicology
First page 621
Last page 625