Evaluating nephrotoxicity of high-molecular-weight organic compounds in drinking water from lignite aquifers
Journal of Toxicology and Environmental Health, Part A
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Abstract
High-molecular-weight organic compounds such as humic acids and/or fulvic acids that are naturally mobilized from lignite beds into untreated drinking-water supplies were suggested as one possible cause of Balkan endemic nephropathy (BEN) and cancer of the renal pelvis. A lab investigation was undertaken in order to assess the nephrotoxic potential of such organic compounds using an in vitro tissue culture model. Because of the infeasibility of exposing kidney tissue to low concentrations of organics for years in the lab, tangential flow ultrafiltration was employed to hyperconcentrate samples suitable for discerning effects in the short time frames necessitated by tissue culture systems. Effects on HK-2 kidney cells were measured using two different cell proliferation assays (MTT and alamarBlue). Results demonstrated that exposure of kidney tissue to high-molecular-weight organics produced excess cell death or proliferation depending on concentration and duration of exposure. Copyright ?? Taylor & Francis Group, LLC.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Evaluating nephrotoxicity of high-molecular-weight organic compounds in drinking water from lignite aquifers |
| Series title | Journal of Toxicology and Environmental Health, Part A |
| DOI | 10.1080/15287390701551274 |
| Volume | 70 |
| Issue | 24 |
| Year Published | 2007 |
| Language | English |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Journal of Toxicology and Environmental Health, Part A |
| First page | 2089 |
| Last page | 2091 |
| Google Analytic Metrics | Metrics page |