In an era when the number of Earth observation satellites is rapidly growing and measurements from satellite sensors are used to address increasingly urgent global issues, often through synergistic and operational combinations of data from multiple sources, it is imperative that scientists and decision-makers are able to rely on the accuracy of Earth observation data products. The characterization and calibration of these sensors, particularly their relative biases, are vital to the success of the developing integrated Global Earth Observation System of Systems (GEOSS) for coordinated and sustained observations of the Earth. This can only reliably be achieved in the postlaunch environment through the careful use of observations by multiple sensor systems over common, well-characterized terrestrial targets (i.e., on or near the Earth's surface). Through greater access to and understanding of these vital reference standard sites and their use, the validity and utility of information gained from Earth remote sensing will continue to improve. This paper provides a brief overview of the use of reference standard sites for postlaunch sensor radiometric calibration from historical, current, and future perspectives. Emphasis is placed on optical sensors operating in the visible, near-infrared, and shortwave infrared spectral regions.