Kinematic similarities between the Sumatra and Puerto Rico Trenches highlight the potential for a mega-earthquake along the Puerto Rico Trench and the generation of local and trans-Atlantic tsunamis. We used the horizontal components of continuous GPS (cGPS) measurements from 10 sites on NE Caribbean islands to evaluate strain accumulation along the North American (NA) - Caribbean (CA) plate boundary. These sites move westward and slightly northward relative to CA interior at rates ≤2.5 mm/y. Provided this motion originates in the subduction interface, the northward motion suggests little or no trench-perpendicular thrust accumulation and may in fact indicate divergence north of Puerto Rico, where abnormal subsidence, bathymetry, and gravity are observed. The Puerto Rico Trench, thus, appears unable to generate mega-earthquakes, but damaging smaller earthquakes cannot be discounted. The westward motion, characterized by decreasing rate with distance from the trench, is probably due to eastward motion of CA plate impeded at the plate boundary by the Bahamas platform. Two additional cGPS sites in Mona Passage and SW Puerto Rico move to the SW similar to Hispaniola and unlike the other 10 sites. That motion relative to the rest of Puerto Rico may have given rise to seismicity and normal faults in Mona Rift, Mona Passage, and SW Puerto Rico.