Viral fitness: definitions, measurement, and current insights
Current Opinion in Virology
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Abstract
Viral fitness is an active area of research, with recent work involving an expanded number of human, non-human vertebrate, invertebrate, plant, and bacterial viruses. Many publications deal with RNA viruses associated with major disease emergence events, such as HIV-1, influenza virus, and Dengue virus. Study topics include drug resistance, immune escape, viral emergence, host jumps, mutation effects, quasispecies diversity, and mathematical models of viral fitness. Important recent trends include increasing use of in vivo systems to assess vertebrate virus fitness, and a broadening of research beyond replicative fitness to also investigate transmission fitness and epidemiologic fitness. This is essential for a more integrated understanding of overall viral fitness, with implications for disease management in the future.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Viral fitness: definitions, measurement, and current insights |
| Series title | Current Opinion in Virology |
| DOI | 10.1016/j.coviro.2012.07.007 |
| Volume | 2 |
| Issue | 5 |
| Year Published | 2012 |
| Language | English |
| Publisher | Elsevier |
| Publisher location | Amsterdam, Netherlands |
| Contributing office(s) | Western Fisheries Research Center |
| Description | 8 p. |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Current Opinion in Virology |
| First page | 538 |
| Last page | 545 |
| Country | United States |
| Google Analytic Metrics | Metrics page |