Applying definitions of “asbestos” to environmental and “low-dose” exposure Levels and health effects, particularly malignant mesothelioma

Journal of Toxicology and Environmental Health, Part B: Critical Reviews
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Abstract

Although asbestos research has been ongoing for decades, this increased knowledge has not led to consensus in many areas of the field. Two such areas of controversy include the specific definitions of asbestos, and limitations in understanding exposure-response relationships for various asbestos types and exposure levels and disease. This document reviews the current regulatory and mineralogical definitions and how variability in these definitions has led to difficulties in the discussion and comparison of both experimental laboratory and human epidemiological studies for asbestos. This review also examines the issues of exposure measurement in both animal and human studies, and discusses the impact of these issues on determination of cause for asbestos-related diseases. Limitations include the lack of detailed characterization and limited quantification of the fibers in most studies. Associated data gaps and research needs are also enumerated in this review.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Applying definitions of “asbestos” to environmental and “low-dose” exposure Levels and health effects, particularly malignant mesothelioma
Series title Journal of Toxicology and Environmental Health, Part B: Critical Reviews
DOI 10.1080/10937404.2011.556045
Volume 14
Issue 1-4
Year Published 2011
Language English
Publisher Taylor & Francis
Contributing office(s) Central Mineral and Environmental Resources Science Center
Description 37 p.
First page 3
Last page 39