This spatial dataset consists of 219 1-kilometer (km) resolution grids depicting estimated agricultural use of 219 pesticides in 1997 for the conterminous United States. Each grid cell value in the national grids of this dataset is the estimated total kilograms (kg) of a pesticide applied to row crops, small grain crops and fallow land, pasture and hay crops, and orchard and vineyard crops within the 1- by 1-km area. Nonagricultural uses of pesticides are not included in this dataset. Of the 219 pesticidesrepresented in the grids, 96 are herbicides, 65 are insecticides, and 37 are fungicides. The remaining 21 compounds are composed of the category "other pesticides", which consist of fumigants, growth regulators, and defoliants. Although this dataset is referenced to 1997, it generally represents a composite of estimated pesticide use during the mid to late 1990s.