Flooding along the Mississippi River and some of its tributaries was detected by the multispectral scanner (MSS) on the Earth Resources Technology Satellite (ERTS-1) on at least three orbits during the spring of 1973. The ERTS data provided the first opportunity for mapping the regional extent of flooding at the time of the imagery. Special optical data processing techniques were used to produce a variety of multispectral color composites enhancing flood-plain details. One of these, a 2-color composite of near infrared bands 6 and 7, was enlarged and registered to 1:250,000-scale topographic maps and used as the basis for preparation of flood image maps. Two specially filtered 3-color composites of MSS bands 5, 6, and 7 and 4, 5, and 7 were prepared to aid in the interpretation of the data. The extent of the flooding was vividly depicted on a single image by 2-color temporal composites produced on the additive-color viewer using band 7 flood data superimposed on pre-flood band 7 images. On May 24, when the floodwaters at St. Louis receded to bankfull stage, imagery was again obtained by ERTS. Analysis of temporal data composites of the pre-flood and post-flood band 7 images indicate that changes in surface reflectance characteristics caused by the flooding can be delineated, thus making it possible to map the overall area flooded without the necessity of a real-time system to track and image the peak flood waves. Regional planning and disaster relief agencies such as the Corps of Engineers, Office of Emergency Preparedness, Soil Conservation Service, interstate river basin commissions and state agencies, as well as private lending and insurance institutions, have indicated strong potential applications for ERTS image-maps of flood-prone areas.