Viral fitness does not correlate with three genotype displacement events involving infectious hematopoietic necrosis virus

Virology
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Abstract

Viral genotype displacement events are characterized by the replacement of a previously dominant virus genotype by a novel genotype of the same virus species in a given geographic region. We examine here the fitness of three pairs of infectious hematopoietic necrosis virus (IHNV) genotypes involved in three major genotype displacement events in Washington state over the last 30 years to determine whether increased virus fitness correlates with displacement. Fitness was assessed using in vivo assays to measure viral replication in single infection, simultaneous co-infection, and sequential superinfection in the natural host, steelhead trout. In addition, virion stability of each genotype was measured in freshwater and seawater environments at various temperatures. By these methods, we found no correlation between increased viral fitness and displacement in the field. These results suggest that other pressures likely exist in the field with important consequences for IHNV evolution.

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Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Viral fitness does not correlate with three genotype displacement events involving infectious hematopoietic necrosis virus
Series title Virology
DOI 10.1016/j.virol.2014.07.003
Volume 464-465
Year Published 2014
Language English
Publisher Elsevier
Contributing office(s) Western Fisheries Research Center
Description 10 p.
Larger Work Type Article
Larger Work Subtype Journal Article
Larger Work Title Virology
First page 146
Last page 155
Country United States
State Washington